Research & Development
A Healthy Life is Within Reach
Cellular quality control has emerged as a central player in ageing. This is not only the case in terms of resistance to age-related diseases, but also to longevity itself, at least in lower organisms. This issue of the journal reviews many aspects of these relationships, while considering various quality control mechanisms at the cell’s disposal. It may not be as easy to discern, however, how all of these devices are integrated to provide a suite of mechanisms that tailor the response to the situation the cell encounters.
This article provides an overview of a compensatory response the cell deploys when it is faced with mitochondrial dysfunction. Rather than eliminating the source of the dysfunction, this response makes the best of a bad situation by adapting cell physiology to the worsening state of affairs. Thus, one could consider this to be a last ditch effort at survival. Surprisingly, the cell (and organism) appears to thrive under these new circumstances, and it can live longer. This certainly surmounts any limitations of quality control mechanisms, and, indeed, it complements them nicely.
The view just presented would neglect an important feature of the compensatory response to mitochondrial dysfunction. This is its firm coordination with other cell quality control mechanisms. It is this aspect that draws our attention in this article. However, there are two additional issues that will be discussed. The first concerns the nature of the underlying coordination and the signals that are involved. The second, and perhaps related question, that will be touched upon briefly is the evolution of the compensatory response.
Currently, it is believed that the clock is an indicator of age and not part of the actual ageing process, but recent work that we deposited on bioRxiv strongly suggests that the process of reversing the clock doesn’t just change the apparent age of the body, it actually reverses ageing itself by restoring the function of our old cells to behave as though they’re young again. Therefore, the clock may not just be telling time; it may actually be controlling time.
Using the latest technology, ageing can be reversed for years. As yet, it is unknown how many times that the process used will trigger the reversal process using a virus to infect an entire body and turn on the reprogramming genes.
Based on laboratory results, this will result in reprogramming genes, that reverses ageing. and regrows neurons.
Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal development, survival, and function in the central nervous system (CNS), being implicated in both neuronal death and neuroprotection. Here, we summarise a body of research investigating the role of nicotinamide in neuronal health within the CNS, with a focus on studies that have shown a neuroprotective effect. Nicotinamide appears to play a role in protecting neurons from traumatic injury, ischaemia, and stroke, as well as being implicated in 3 key neurodegenerative conditions: Alzheimer’s, Parkinson’s, and Huntington’s diseases. A key factor is the bioavailability of nicotinamide, with low concentrations leading to neurological deficits and dementia and high levels potentially causing neurotoxicity. Finally, nicotinamide’s potential mechanisms of action are discussed, including the general maintenance of cellular energy levels and the more specific inhibition of molecules such as the nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin 1 (SIRT1).
Mitochondria to Nucleus signalling
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
The Secret to Ageing in Reverse
Learning how to Live as Vibrantly and Energetically for as Long as you can.
Product Description: NMN (Nicotinamide Mononucleotide) Dietary Supplement
Unlock the potential of healthy aging with our premium NMN (Nicotinamide Mononucleotide) dietary supplement. NMN is a cutting-edge molecule that has gained significant attention for its potential to support overall well-being and longevity. Our NMN supplement offers a convenient way to incorporate this exciting compound into your daily routine.
Key Benefits:
Cellular Energy Boost: NMN plays a crucial role in the production of NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for cellular energy production. By promoting efficient energy metabolism, NMN helps enhance vitality and endurance.
Aging Support: Research suggests that NMN may support healthy aging by activating sirtuins, a group of proteins associated with longevity and cellular resilience. This activation has the potential to promote cellular repair and combat age-related decline.
Cognitive Function: NMN's potential neuroprotective properties may contribute to improved cognitive function and brain health. By maintaining the vitality of neurons and supporting synaptic plasticity, NMN may help with memory and cognitive performance.
Cardiovascular Health: NMN's ability to support healthy blood vessel function and circulation may contribute to cardiovascular wellness. It may aid in maintaining optimal blood pressure levels and promoting overall heart health.
Metabolic Health: NMN may play a role in regulating metabolism by influencing mitochondrial function and promoting efficient energy utilization. This reaction can have positive effects on weight management and metabolic balance.
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Our NMN dietary supplement is crafted with the utmost care and quality. We source our NMN from reputable suppliers. Each batch is then rigorously tested for purity and potency. Our capsules are easy to swallow and designed for optimal absorption, allowing you to experience the potential benefits of NMN with convenience.
Directions for Use:
Take 500 mg (1 Scoop) or 1 g (2 Scoops) of our NMN supplement daily. Your NMN supplement should be taken each morning before food immediately after your NR supplement for maximum effect.
Note: This product is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider before starting a course on any new dietary supplement.
Critical Studies on NMN:
"Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice" - Link to Study
"Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion" - Link to Study
"SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis" - Link to Study
"Nicotinamide mononucleotide enhances mitochondrial oxidative metabolism and protects murine cardiomyocytes from oxidative stress" - Link to Study
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